Accession Number:

ADA582694

Title:

Photonic Breast Tomography and Tumor Aggressiveness Assessment

Descriptive Note:

Annual summary 15 Jun 2011-14 Jun 2012

Corporate Author:

CITY UNIV OF NEW YORK RESEARCH FOUNDATION

Report Date:

2012-07-01

Pagination or Media Count:

35.0

Abstract:

The tasks performed and the progresses made during the fourth year include the following 1 carrying out research on the development of noninvasive near-infrared NIR diffuse optical imaging DOI approaches for the detection of breast tumors in the early stages of growth when they are more amenable to treatment and 2 training of CCNY researchers at MSKCC in magnetic resonance spectroscopic imaging MRSI for the detection of lactate in tumors. The NIR optical imaging research involved the development of time reversal optical tomography TROT for imaging single absorbing and single scattering targets as a function of position, and two targets as a function of separation between them and the adaptation and comparison of Principal Component Analysis PCA and Nonnegative Matrix Factorization NMF methods to the DOI problem and comparing them with previously developed OPTICA optical tomography using independent component analysis. These approaches were demonstrated to be suited for detecting and locating small targets in tissue-simulating turbid media. MRSI investigation of lactate holds promise for assessment of tumor aggressiveness. We also have initiated the development of numerical algorithms for fluorescence tomography, since it has the potential to provide higher contrast as well as molecular and functional information through the use of exogenous fluorophores. A new research pre-proposal was developed and submitted to CDMRP 2011 BCRP Idea Award category for funding.

Subject Categories:

  • Medicine and Medical Research
  • Optical Detection and Detectors
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE