Survival and Injury Outcome After TBI: Influence of Pre- and Post-Exposure to Caffeine
Final rept. 15 Sep 2010-14 Sep 2012
LEGACY EMMANUEL HOSPITAL AND HEALTH CENTER PORTLAND OR
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Soldiers on active duty consume large amounts of caffeine, however little is known how chronic and acute caffeine use affects the outcome of traumatic brain injury TBI. Data from our lab document that an acute dose of caffeine given after severe TBI in rats results in a dramatic reduction in mortality. The experiments presented herein provide a systematic analysis how acute versus chronic caffeine administered before or after TBI - modeled here in the rat lateral fluid percussion injury FPI model - affects survival and morbidity following TBI. We present data demonstrating that i chronic caffeine consumption is safe in regards to acute outcome parameters following TBI, ii default caffeine withdrawal after TBI is beneficial, whereas chronic caffeine consumption after TBI should be avoided, and iii a single bolus of caffeine after severe TBI can prevent lethal outcome, regardless of pre-injury caffeine consumption. We demonstrate that a wide dose range of caffeine is safe, with a moderate dose equivalent to 2-3 cups of coffee for a human was most effective.
- Medicine and Medical Research