Accession Number:

ADA582389

Title:

Studying Protein Synthesis-Dependent Synaptic Changes in Tuberous Sclerosis

Descriptive Note:

Annual rept. 1 Apr 2012-31 Mar 2013

Corporate Author:

MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s):

• Yoshii, Akira
• Constantine-Patton, Martha

Report Date:

2013-04-01

Pagination or Media Count:

12.0

Abstract:

We are testing the hypothesis that the balance between excitation and inhibition is skewed in TSC brains and that this synaptic dysregulation is caused by altered protein synthesis. We have found that the imbalance between excitation and inhibition using biochemical assays and electrophysiology. Furthermore, calcium imaging show hyperexcitable neuronal activities in TSC-1 deleted neurons. These results further support our hypothesis. Correction of this synaptic dysregulation will hopefully provide a new therapeutic target to neurological symptoms in TSC such as epilepsy, mental retardation and autistic behaviors.

Descriptors:

• *BIOSYNTHESIS
• *MUTATIONS
• *PROTEINS
• BRAIN
• EPILEPSY
• GENES
• NERVE CELLS
• PLASTIC PROPERTIES
• RETARDATION

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE