Preliminary Mathematical Model for Jet Fuel Exacerbated Noise-Induced Hearing Loss
Interim rept. Oct 2011-Dec 2012
AIR FORCE RESEARCH LAB WRIGHT PATTERSON AFB OH HUMAN PERFORMANCE WING (711TH) HUMAN EFFECTIVENESS DIR/ BIOEFFECTS DIVISION
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Laboratory studies support the potential for jet fuel to promote noise induced hearing loss. Noise alone induces hearing loss due to loss of hair cells in the cochlea, associated with oxidative stress. Jet fuel toxicity in association with noise may be at least partially explained by increased free radical production and oxidative stress at the cellular level, resulting in hair cell dysfunction and loss. This project combines a physiologically-based pharmacokinetic PBPK model to describe jet fuel component concentrations in the cochlea with pharmacodynamic PD models of free radical formation in the cochlea by both noise and jet fuel components, and mathematical models to predict the combined impact on hair cell functionality and loss. Further development of this preliminary combined PBPK-PD model of JP-8 induced hearing loss with noise will provide the basis for estimating the potential risk to humans exposed to the same chemical and sound scenarios in occupational settings.
- Anatomy and Physiology
- Medicine and Medical Research
- Operations Research