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Hypertonic Saline Dextran (HSD) in a Complex Military Injury - A Preclinical Study
DSTL ARMOUR GROUP PORTON DOWN (UNITED KINGDOM)
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Recent data from current conflicts indicate that a significant proportion of severely injured military casualties result from explosive events. Although these are evacuated to surgical care as quickly as possible, extended evacuation is sometimes enforced. Significant logistical and potential physiological advantage might be attained by employing low volume resuscitation with hypertonic intravenous fluids. Current military practice for initial far-forward resuscitation involves hypotensive resuscitation with isotonic crystalloids. We have reported, based on a porcine model of severe haemorrhage that prolonged hypotensive resuscitation causes substantial physiological deterioration. A hybrid strategy using 0.9 saline of initial hypotensive 60 min followed by normotensive resuscitation offered significant physiological benefit after haemorrhage alone and significantly better survival after combined haemorrhage and blast injury.
APPROVED FOR PUBLIC RELEASE