Accession Number:

ADA581932

Title:

Hypertonic Saline Dextran (HSD) in a Complex Military Injury - A Preclinical Study

Descriptive Note:

Corporate Author:

DSTL ARMOUR GROUP PORTON DOWN (UNITED KINGDOM)

Personal Author(s):

• Watts, Sarah

Report Date:

2010-04-01

Pagination or Media Count:

21.0

Abstract:

Recent data from current conflicts indicate that a significant proportion of severely injured military casualties result from explosive events. Although these are evacuated to surgical care as quickly as possible, extended evacuation is sometimes enforced. Significant logistical and potential physiological advantage might be attained by employing low volume resuscitation with hypertonic intravenous fluids. Current military practice for initial far-forward resuscitation involves hypotensive resuscitation with isotonic crystalloids. We have reported, based on a porcine model of severe haemorrhage that prolonged hypotensive resuscitation causes substantial physiological deterioration. A hybrid strategy using 0.9 saline of initial hypotensive 60 min followed by normotensive resuscitation offered significant physiological benefit after haemorrhage alone and significantly better survival after combined haemorrhage and blast injury.

Descriptors:

• *BLAST
• *BLOOD CHEMISTRY
• *DEXTRAN
• *SALINE SOLUTION
• *WOUNDS AND INJURIES
• BLOOD PRESSURE
• EQUATIONS
• EXPLOSIONS
• HEMORRHAGIC SHOCK
• RESUSCITATION
• STATISTICAL ANALYSIS

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Physical Chemistry
• Explosions

Distribution Statement:

APPROVED FOR PUBLIC RELEASE