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Encapsulated Solid-Liquid Phase Change Nanoparticles as Thermal Barcodes for Highly Sensitive Detections of Multiple Lung Cancer Biomarkers
Final rept. 15 Sep 2010-14 Sep 2012
UNIVERSITY OF CENTRAL FLORIDA ORLANDO
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This project studies the feasibility of using solid-liquid phase change nanoparticles to detect multiple cancer biomarkers for enhanced cancer detection at early stage. With the support from DOD-LCRP, we have proved the new signal transduction mechanism based on solidliquid phase change nanoparticles works for the detection of multiple proteins. A series of metal and alloy nanoparticles have been made and used for the detection of multiple proteins. The melting peaks are used for qualitative and quantitative detection of biomarkers. This grant supported a graduate student and a postdoc. This project has produced 10 peer-reviewed publications, and the result has been used to obtain an NSF-CAREER project in 2011, as well as two grants to NIH and National Institute of Justice in 2012.
APPROVED FOR PUBLIC RELEASE