Viral Immunotherapy to Eradicate Subclinical Brain Metastases
Annual rept. 1 September 2011 31 August 2012
PITTSBURGH UNIV PA
Pagination or Media Count:
To establish an animal model of breast cancer metastases to the brain and to use this model to demonstrate that anti-tumor host memory T-cells can be re-activated to enter and destroy early BM by viral infection of Her2-positive breast BM by a recombinant vesicular stomatitis virus VSV, which liberates tumor antigens by viral oncolysis and induces acute inflammation in BM and CSF via the cytokine transgenes it carries andor by adoptive transfer of cytotoxic, cytokine-producing natural killer NK cells capable of accumulating in smaller metastases of the brain.
- Medicine and Medical Research