Corneal Protection for Burn Patients
Annual rept. 1 Jul 2011-30 Jun 2012
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE BETHESDA MD
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The overall goal of this research is to preserve vision of patients recovering from severe facial burns by providing an improved method to reduce development of corneal defects, inflammation, infection and opacification. Scope To further improve and understand the properties of the degradation-resistant crosslinked amniotic membranes for treating cornea of burn patients that were produced in Years 1 and 2. Major findings Identified membrane stiffness as a critical parameter for a successful cornea-protective membrane and quantitatively assessed this parameter. Monolayer crosslinked amnions showed low stiffness and excellent enzyme degradation resistance. Tri-layer membranes showed excellent enzyme degradation resistance but their high stiffness made eliminated them from further consideration. Showed that two of the three crosslinking methods to produce stable membranes also decreased the levels of a soluble pro-healing factor. Constructed an amnionencapsulated hydrogel lens with an improved enzyme resistance to be used to maintain hydration on the cornea surface of patients with peri-orbital scarring that prevents blinking.
- Anatomy and Physiology
- Medicine and Medical Research