Development of Pantothenate Analogs That Can Treat Combat-Related Infections
Annual rept. 1 Jan 2012-31 Dec 2012
TORONTO UNIV (ONTARIO)
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We solved the co-crystal structures of SaPanK with MT-190 and KpPanK with MT-183. Based on these structures, we synthesized 11 new compounds that fit to the Pan analog binding site of SaPanK or KpPanK. In addition, we showed qualitative bacterial killing efficiency of these 11 compounds by agar diffusion and their cytotoxicity to HepG2 cells. These new compounds will be the basis for further optimization to develop a novel class of narrow-spectrum antibiotics against the multidrug resistant strains of S. aureus and K. pneumoniae.
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