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Developing a Mouse Model of Sensory and Cognitive Deficits for Multiple Sclerosis
Annual rept. 15 Jun 2011 - 14 Jun 2012
WAYNE STATE UNIV DETROIT MI
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In this project, we have been developing a novel mouse model of multiple sclerosis with a focus on cognitive dysfunction associated with defective myelin. We have developed this model using homologous recombination in embryonic stem cells and have obtained homologous recombinants. However, we have experienced difficulties in deriving mice from the recombinant cells which has delayed our progress toward completion of our goals. We have now repeated the homologous recombinant experiments and are screening for embryonic stem cell clones to be used in homologous recombinant injections. In addition to generation of our novel model, we have been developing neurophysiological techniques to assess cognitive deficits in our novel mouse model. These experiments involve using the auditory pathway to test neural processing in the superior olivary complex, and are proceeding well.
APPROVED FOR PUBLIC RELEASE