Accession Number:

ADA581471

Title:

Molecular Signatures of Chronic Pain Subtypes

Descriptive Note:

Annual rept. 13 Dec 2011-12 Dec 2012

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

• Shaw, Andrew D.

Report Date:

2013-01-01

Pagination or Media Count:

80.0

Abstract:

This project continues to be a biomarker discovery program focusing on the causes of persistent pain after traumatic amputation in the combat setting. In the second year we have 1 maintained the necessary regulatory approval at WRMC and Duke University. We have obtained and maintained documents for approval by MRMC 2 maintained our interactive, secure web based data collection system 3 populated our biorepository at Duke with bioresource collected from 71 patients enrolled at WRNMMC 4 conducted further on-site visits and investigator meetings at WRNMMC 5 submitted samples to the Duke Core Lab facilities for proteomic, metabolomic, genomic, genetic and epigenetic assays. We have received our initial pilot results and presented these in Washington DC at ASA. We have published two more papers and are now collecting our validation cohort of patients. Our overall progress is slightly ahead of target, given the lengthy administrative delays during year one. Lastly, we have been funded by DOD to conduct an intervention trial at WRNMMC and the Durham VAMC of valproate for the prevention of amputation induced chronic pain.

Descriptors:

• *AMPUTATION
• *PAIN
• DELAY
• GENETICS
• INTERVENTION
• MOLECULES
• PATIENTS
• SETTING(ADJUSTING)
• SYMPOSIA
• TARGETS
• TRAUMA

Subject Categories:

• Medicine and Medical Research
• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE