Advanced MRI in Blast-related TBI
Final rept. 1 Sep 2008-30 Jun 2012
WASHINGTON UNIV ST LOUIS MO
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The purpose of the research effort was to test two advanced MRI methods, DTI and resting-state fMRI, in active-duty military blast-related TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. The goal was to determine whether these methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding postinjury rehabilitation, and developing novel therapeutics. The overarching hypothesis guiding this project is that traumatic axonal injury is a principal cause of impaired brain function following blast-related TBI.
- Anatomy and Physiology
- Medicine and Medical Research