Accession Number:

ADA581398

Title:

Advanced MRI in Blast-related TBI

Descriptive Note:

Final rept. 1 Sep 2008-30 Jun 2012

Corporate Author:

WASHINGTON UNIV ST LOUIS MO

Personal Author(s):

• Brody, David L.

Report Date:

2012-07-01

Pagination or Media Count:

131.0

Abstract:

The purpose of the research effort was to test two advanced MRI methods, DTI and resting-state fMRI, in active-duty military blast-related TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. The goal was to determine whether these methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding postinjury rehabilitation, and developing novel therapeutics. The overarching hypothesis guiding this project is that traumatic axonal injury is a principal cause of impaired brain function following blast-related TBI.

Descriptors:

• *MAGNETIC RESONANCE IMAGING
• *TRAUMATIC BRAIN INJURIES
• BLAST
• BRAIN
• MILITARY PERSONNEL
• NERVE FIBERS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE