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Novel High-Throughput Drug Screening Platform for Chemotherapy-Induced Axonal Neuropathy
Annual rept. 1 May 2012-30 Apr 2013
JOHNS HOPKINS UNIV BALTIMORE MD
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Taxol is an antineoplastic agent, which is used for the treatment of various cancer types such as breast, ovarian, lung, bladder, etc. It disrupts the microtubule assembly and accumulates in the dorsal root ganglion DRG. The side effect of Taxol is peripheral neuropathy. DRG neurons are sensory nerve cells, and their cell bodies are bundled together lying outside of the spinal cord - ganglia. DRG neurons are accessible and convenient to harvest in embryonic animals and they survive well in culture.
APPROVED FOR PUBLIC RELEASE