DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
ADA581344
Title:
Whole Brain Networks for Treatment for Epilepsy
Descriptive Note:
Annual rept. 1 Jul 2011-30 Jun 2012
Corporate Author:
CLEVELAND CLINIC FOUNDATION OH
Report Date:
2012-07-01
Pagination or Media Count:
14.0
Abstract:
The most significant finding during this research period was a clear theoretical foundation for partial differential equation PDE-based tractography that inherently includes constraints within the formalism. This foundation has enabled us to make rational choices in developing an algorithm capable of mapping whole-brain networks of axonal connectivity. The algorithm satisfies two necessary conditions 1 it can identify connections invisible to standard streamline throughout the entire brain and 2 it is fast enough for practical use. Although correlation with gold-standard electrophysiology measurements of connectivity is weak, the developed formalism will make it practical to incorporate information from other imaging modalities with the long range goal of developing a noninvasive biomarker for traumatic brain injury-related epilepsy.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE