Accession Number:

ADA581344

Title:

Whole Brain Networks for Treatment for Epilepsy

Descriptive Note:

Annual rept. 1 Jul 2011-30 Jun 2012

Corporate Author:

CLEVELAND CLINIC FOUNDATION OH

Personal Author(s):

• Sakaie, Ken

Report Date:

2012-07-01

Pagination or Media Count:

14.0

Abstract:

The most significant finding during this research period was a clear theoretical foundation for partial differential equation PDE-based tractography that inherently includes constraints within the formalism. This foundation has enabled us to make rational choices in developing an algorithm capable of mapping whole-brain networks of axonal connectivity. The algorithm satisfies two necessary conditions 1 it can identify connections invisible to standard streamline throughout the entire brain and 2 it is fast enough for practical use. Although correlation with gold-standard electrophysiology measurements of connectivity is weak, the developed formalism will make it practical to incorporate information from other imaging modalities with the long range goal of developing a noninvasive biomarker for traumatic brain injury-related epilepsy.

Descriptors:

• *TRAUMATIC BRAIN INJURIES
• ELECTROPHYSIOLOGY
• EPILEPSY
• FOUNDATIONS(STRUCTURES)
• NETWORKS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE