Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches
Final rept. 1 Jul 2008 - 30 Jun 2012
KENTUCKY UNIV LEXINGTON
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Our findings reveal that EMMPRIN immunoreactivity was primarily detected among the glandular epithelial cells EMMPRIN levels progressively increased with increasing age of TRAMP mice 6-27 wks with the highest detected in liver metastases. Quantitative analysis revealed that by 27-wks an age exhibiting highly aggressive prostate tumor phenotype, EMMPRIN expression increased significantly P0.001. These results suggest that EMMPRIN may have diagnostic value in prostate cancer detection in advanced disease.
- Medicine and Medical Research