The Root Cause of Post-traumatic and Developmental Stress Disorder
Annual rept. 1 Mar 2009 - 28 Feb 2010
TEXAS A AND M UNIV COLLEGE STATION HEALTH SCIENCE CENTER
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Our overarching scientific hypothesis holds that serotonergic influences on brain development driven by genetics and early experience induce a variation of normal brain anatomy that makes the brain highly susceptible to the effects of severe stress. We are studying this question using both clinical and basic approaches. New findings from our lab funded by VA support the existence of an anatomical phenotype conferring susceptibility to depression, and the current work seeks to extend these findings to PTSD. Project 2 Fluoxetine in active duty troops has begun to enroll subjects at Fort Hood and will provide genetic material for this project. To allow use of new VA MRI VA research facilities, and to improve design, power and military application, a revised change in scope to project 5 has been submitted to allow all the work to be performed in OEFOIF veterans. In the cellular level anatomical study, 15 brains have been identified and tissue processing is being initiated. The animal project work is approximately 12 finished and task 2 is being initiated.
- Anatomy and Physiology