Development of Intra-Articular Drug Delivery to Alter Progression of Arthritis Following Joint Injury
Final rept. 15 Sep 2010-14 Mar 2013
DUKE UNIV DURHAM NC
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The work in this study addresses the development of post-traumatic osteoarthritis PTOA and seeks to develop a basis for future therapeutic interventions. Currently, the only disease-modifying treatment for articular fractures is surgical intervention. Estimates suggest as many as 12 of all symptomatic osteoarthritis patients are post-traumatic 1. At the present time, the state of the art treatment for displaced articular fractures in weight bearing joints is surgical stabilization of the fracture with anatomic restoration of the articular surface when possible. Even with optimal treatment, displaced articular fractures in the lower extremity have a 10-20 incidence of post-traumatic osteoarthritis 2. Currently, there is no pharmacological intervention, either systemically or locally, that has been shown to decrease the incidence of post-traumatic osteoarthritis. Growing evidence suggests that the inflammatory environment of the joint may also play a critical role in the development and progression of post-traumatic arthritis.
- Anatomy and Physiology
- Medicine and Medical Research