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Enhanced Healing of Segmental Bone Defects by Modulation of the Mechanical Environment
Annual rept. 30 Sep 2011-29 Sep 2012
BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
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This report covers the second year of a three-year project that examines the hypothesis that the healing of critical size femoral defects in the rat in response to recombinant, human bone morphogenetic protein-2 BMP-2 is enhanced by reverse dynamization . In reverse dynamization, the defect is initially fixed loosely. Once healing has commenced, stiffness is increased. This is the opposite of current clinical practice of fixing osseous defects as stiffly as possible. When dynamization is used in the standard fashion, it starts with high stiffness fixation and is followed by low stiffness fixation. During the first year of the study, we provided proof of principle data demonstrating that reverse dynamization indeed accelerated healing of a rat femoral defect in the presence of BMP-2, and improved bone quality. This covered most of Specific Aims 1 and 2 of the original proposal.
APPROVED FOR PUBLIC RELEASE