Accession Number:

ADA581127

Title:

Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury

Descriptive Note:

Annual rept. 2012-28 Feb 2013

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

• Long, Joseph

Report Date:

2013-03-01

Pagination or Media Count:

84.0

Abstract:

We hypothesize that the biomechanical perturbations of the brain that yield blastinduced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure BOP i.e. primary blast and head acceleration andor impact i.e. tertiary blast. The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.

Descriptors:

• *BRAIN
• *MEDICAL RESEARCH
• *TRAUMATIC BRAIN INJURIES
• BIOMECHANICS
• BLAST
• CONTROL
• IMPACT
• MODELS
• PERTURBATIONS
• RODENTS
• TRAUMA
• WOUNDS AND INJURIES
• YIELD

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE