Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury
Annual rept. 2012-28 Feb 2013
GENEVA FOUNDATION TACOMA WA
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We hypothesize that the biomechanical perturbations of the brain that yield blastinduced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure BOP i.e. primary blast and head acceleration andor impact i.e. tertiary blast. The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.
- Medicine and Medical Research