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Green Tea Modulation of Obesity and Breast Cancer Risk

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Annual summary rept. 15 Mar 2012-14 Mar 2013

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With estimated 232,340 new cases in 2013, breast cancer continues to be the most frequently diagnosed non-skin cancer among American women. It is also predicted that 39,620 women lose their lives as a result of breast cancer in 2013 in the United Sates, which still keeps the breast cancer as the second leading cause of cancer death. Obesity is a known risk factor for breast cancer in postmenopausal women. Green tea consumption has been shown to be related with decreased body weight and it is thought that it may also reduce inflammation. The goal of this training grant is to study changes in the obesity and energy-related hormones as well as inflammatory markers in healthy postmenopausal women at high risk of breast cancer due to dense breast tissue who consume green tea supplements containing 800 mg epigallocatechin-3-gallate EGCG daily for 12 months. Major milestones of this study include recruiting and randomizing all of the training grant study participants, and completing the study for 90 of the target sample size. It is expected that the last participant completes the study for this training grant by the end of July 2013. Lastly, analyses of all biological samples in serum and plasma will start in early May 2013, and it is anticipated that the last run of analyses to be finished by the middle of August 2013.

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  • Medicine and Medical Research

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