Exercise and Osteoporosis: A Dose-Response Meta-Analysis
Final rept. 1 May 2010-30 Apr 2013
WEST VIRGINIA UNIV MORGANTOWN
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The overall purpose of this two-year project with a one-year no-cost extension was to use the aggregate data, meta-analytic approach to determine the effects of exercise on bone mineral density BMD at the femoral neck FN and lumbar spine LS in adult men and women 18 years of age and older. In both premenopausal and postmenopausal women, statistically significant and clinically relevant improvements were found for both FN and LS BMD p 0.05 for all. However, no such differences were observed in men. With respect to dose-response, several associations were found between exercise-induced changes in FN and LS among premenopausal and postmenopausal women but none for load rating. Insufficient data were available to examine load ratings in men. The results of this important work suggest that exercise improves BMD at the FN and LS in both premenopausal and postmenopausal women. However, insufficient evidence currently exists to support such an effect in men. A dire need exists for additional randomized controlled trials in men as well as dose-response studies using more valid and reliable load rating instruments in both men and women.
- Medicine and Medical Research