Validation of an In Vitro Bioaccessibility Test Method for Estimation of Bioavailability of Arsenic from Soil and Sediment
Final rept. 2008-2012
EXPONENT INC BOULDER CO
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A method is described for measuring the in vitro bioaccessibility IVBA of arsenic in soil or soil-like media, and using the measured IVBA value to estimate the relative bioavailability RBA in swine or monkeys using empiric regression models developed from 20 swine or 17 monkey calibration soils. The correlation coefficients for the models are high 0.85 for swine, 0.87 for monkey, and the precision of the method is high, both within and between laboratories. This method is the most thoroughly tested, calibrated, and validated IVBA approach for estimation of arsenic RBA that has been described to date.
- Inorganic Chemistry