Accession Number:

ADA576914

Title:

Photoacoustic Imaging of Epilepsy

Descriptive Note:

Annual rept. 1 Apr 2012-30 Mar 2013

Corporate Author:

FLORIDA UNIV GAINESVILLE

Personal Author(s):

• Jiang, Huabei

Report Date:

2013-04-01

Pagination or Media Count:

30.0

Abstract:

This research is aimed at developing a new imaging approach, called Photoacoustic tomography PAT , for non-invasively tracking dynamical changes during seizure occurrence. The project will develop imaging hardware and software, and conduct phantomin vivo experiments to achieve the proposed goals. During the fourth year of this project, We have developed and validated a rat model of temporal lobe epilepsy. We have performed extensive in vivo experiments to achieve concurrent EEG and PAT recordings. Interesting results are obtained that may be significant for seizure prediction and for neurovascular coupling studies. We have designed and constructed a light-weighted animaltransducer interface that can be used for chronic monitoring of freely moving animals.

Descriptors:

• *EPILEPSY
• BLOOD VESSELS
• COUPLING(INTERACTION)
• ELECTROENCEPHALOGRAPHY
• NERVOUS SYSTEM
• RATS
• RECORDING SYSTEMS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE