Accession Number:

ADA576665

Title:

A Placebo-Controlled Augmentation Trial of Prazosin for Combat Trauma PTSD

Descriptive Note:

Annual rept. 1 Jun 2010-31 May 2011

Corporate Author:

SEATTLE INST FOR BIOMEDICAL AND CLINICAL RESEARCH SEATTLE WA

Personal Author(s):

Report Date:

2011-06-01

Pagination or Media Count:

5.0

Abstract:

This study consists of a 14-week, two parallel group, randomized placebo controlled trial to evaluate the efficacy and tolerability of the alpha-1 adrenergic antagonist, prazosin, for reducing trauma nightmares and sleep disturbance and improving global function and sense of well-being, in 210 OIF and OEF combat-exposed returnees with PTSD and persistent trauma-related nightmares and disrupted sleep. A secondary aim is to assess efficacy of prazosin for reducing total PTSD symptoms, reducing symptoms of depression, improving quality of life, and reducing alcohol craving.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE