Spectroscopic Biomarkers for Monitoring Wound Healing and Infection in Combat Wounds
Annual rept. 30 Sep 2011-29 Sep 2012
GENEVA FOUNDATION TACOMA WA
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This proposal focuses on the use of multimodal imaging and spectroscopy of post-traumatic soft tissue and bone to assess wound healing. Combining infrared IR imaging, near-infrared spectroscopic NIRS imaging, and visible reflectance spectroscopic VRS imaging with Raman Spectroscopy RS will enable the surgeon to probe the tissue with a two-dimensional, real-time approach. This assessment allows optimal determination of the viability of damaged tissue, the suitability of the tissue environment for healing, the potential for wound infection and ectopic bone formation based on the degree of tissue compromise, and development of potential objective indicators for early limb salvage versus amputation. These imaging systems are currently available and readily applicable for clinical use. Combining these technologies in a multimodal system holds great promise in permitting the surgeon to make a better objective assessment of the viability of tissues in ways that have not previously been possible.
- Medicine and Medical Research
- Atomic and Molecular Physics and Spectroscopy