Accession Number:

ADA574962

Title:

Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer

Descriptive Note:

Annual summary rept. 15 Sep 2011-14 Sep 2012

Corporate Author:

OKLAHOMA STATE UNIV STILLWATER

Personal Author(s):

Report Date:

2012-10-01

Pagination or Media Count:

26.0

Abstract:

In the year-2, we advanced our understandings regarding the challenges of trans-rectal fluorescence diffuse optical tomography FDOT of negative-contrast targets, for prostate cancer detection by using zinc-specific fluorescent probe. The challenges are evaluated through analytical, numerical, and experimental methods. Specifically, we developed a novel analytical approach to quantify diffuse photon propagation in an outward-imaging geometry that idealizes imaging prostate tissue by using transrectal optical applicator. we demonstrated numerically that DOTFDOT measurements is less sensitive to a negative-contrast target than to a positive-contrast target, and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. we conducted trans-rectal ultrasound-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. Negative-contrast target is found very challenging to reconstruct.

Subject Categories:

  • Medicine and Medical Research
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE