Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer
Annual summary rept. 15 Sep 2011-14 Sep 2012
OKLAHOMA STATE UNIV STILLWATER
Pagination or Media Count:
In the year-2, we advanced our understandings regarding the challenges of trans-rectal fluorescence diffuse optical tomography FDOT of negative-contrast targets, for prostate cancer detection by using zinc-specific fluorescent probe. The challenges are evaluated through analytical, numerical, and experimental methods. Specifically, we developed a novel analytical approach to quantify diffuse photon propagation in an outward-imaging geometry that idealizes imaging prostate tissue by using transrectal optical applicator. we demonstrated numerically that DOTFDOT measurements is less sensitive to a negative-contrast target than to a positive-contrast target, and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. we conducted trans-rectal ultrasound-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. Negative-contrast target is found very challenging to reconstruct.
- Medicine and Medical Research
- Inorganic Chemistry