Advanced MRI in Acute Military TBI
Annual rept. 1 Sep 2011-31 Aug 2012
WASHINGTON UNIV ST LOUIS MO
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The objective of the project is to test two advanced MRI methods, DTI and resting-state fMRI correlation analysis, in military TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. An additional objective is to test the interaction of candidate genetic vulnerability factors with patterns of injury. These combined methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis is that traumatic axonal injury, interacting with genetic vulnerability factors, is a principal cause of impaired brain function following blast-related and non-blast-related TBI. The study is a prospective longitudinal study with subject enrollment and initial evaluation at Landstuhl Regional Medical Center in Landstuhl Germany. Follow-up evaluations are performed at Washington University in St Louis. Starting this year, additional subjects have been enrolled at 2 sites in Afghanistan To date, 223 subjects have been enrolled at LRMC and 230 subjects have been enrolled in Afghanistan. 145 complete follow-up evaluations have been performed. There have been no adverse events.
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