Accession Number:

ADA574634

Title:

Identification of Small Molecule Inhibitors of microRNA Involved in Chemoresistance and Cancer Stem Cells for Ovarian Cancer Intervention

Descriptive Note:

Annual rept. 1 Mar 2011-29 Feb 2012

Corporate Author:

H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL

Personal Author(s):

Report Date:

2012-03-01

Pagination or Media Count:

30.0

Abstract:

During last year, we have screened NCI Diversity Set, Nature Compound and Clinical Collection 1 and 2 libraries using cell-based assay and have identified 22 and 35 candidate compounds that inhibit miR-19ab and miR-221222, respectively. Furthermore, we have characterized the specificity of these candidates as well as potential inhibitors of miR-214 and have identified 2 specific inhibitors for miR-214, 3 for miR-221222 and 2 for miR-19ab. We are currently investigating their antitumor activity in cell culture and animal model.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE