Human-Compatible Animal Models for Preclinical Research on Hormones in Breast Cancer
Final rept. 1 Sep 2010-31 Aug 2012
CINCINNATI UNIV OH
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Our most significant findings during the second year of work included the following 1. The PRL-humanized mice synthesize and secrete hPRL that is fully biologically active at the human PRL receptor as evidenced by activation of STAT5 in human breast cancer cells. 2. Our proof of concept experiment in which human breast cancer xenografts were studied in hosts bearing anterior pituitary grafts under the renal capsules, supports the hypothesis that elevated circulating hPRL leads to increased growth of human breast cancer tumors. The rate of growth of xenografts was greatest in hosts bearing hPRL-secreting pituitary grafts as compared to those bearing mPRL-secreting or PRL-knock out pituitary grafts. 3. We now have the PRL-humanized mice on the immunodeficient SCID background and are planning multiple collaborations with other investigators.
- Medicine and Medical Research