Accession Number:

ADA574565

Title:

Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury

Descriptive Note:

Annual rept. 30 Sep 2011-29 Oct 2012

Corporate Author:

UTAH UNIV SALT LAKE CITY

Report Date:

2012-10-01

Pagination or Media Count:

60.0

Abstract:

Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important milestones have been the validation and beginning of data collection for remote telemetric monitoring and two-photon microscopy. These are both technology-intensive, cutting edge techniques, and two-photon microscopy was a new technique for our group. We have also collected publication-ready work using our more familiar optical imaging techniques, showing that the immunological activation associated with TBI alters brain excitability.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE