Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR-CAT)
Annual rept. 26 Sep 2010-25 Sep 2011
PITTSBURGH UNIV PA
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Cardiopulmonary resuscitation CPR can save victims of normovolemic cardiac arrest CA, e.g., ventricular fibrillation. During exsanguination CA from trauma, however, CPR, even with an emergency department ED thoracotomy and open chest CPR, doesn t work. Emergency Preservation and Resuscitation EPR was developed to rapidly preserve the organism during ischemia, using hypothermia, drugs, and fluids, to buy time for transport and resuscitative surgery. The purpose of this study is to test the feasibility of rapidly inducing profound hypothermia 10oC with an aortic flush in trauma victims that have suffered CA and failed standard resuscitative efforts to enable resuscitative surgery and delayed resuscitation with cardiopulmonary bypass. The primary outcome variable will be survival to hospital discharge with minimal neurologic dysfunction.
- Medicine and Medical Research