Molecular Profiles for Lung Cancer Pathogenesis and Detection in U.S. Veterans
Annual rept. 20 Sep 2011-19 Sep 2012
M D ANDERSON CANCER CENTER HOUSTON TX
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During our second year of research, we derived expression profiles signifying the molecular field cancerization in early-stage NSCLC. We also showed that the field cancerization profiles, identified in distal airways of resected specimens, are, at least in part, relevant to the field of injury and differentially expressed between large airways of patients with and without lung cancer. In addition, our profiling studies revealed airway expression patterns that are significantly modulated with distance from corresponding tumors and, importantly, concordantly dissimilar between tumors and paired uninvolved normal lung, pinpointing to their probable roles in pathogenesis. In addition, we validated the differentially expression of several key site-dependent and-independent field cancerization markers. Furthermore, we found that, LAPTM4B, a putative oncogene with no known role in lung carcinogenesis and one of top 5 site-dependent field cancerization markers that increased with shorter distance from tumors in our profiling studies, was a positive mediator of the malignant phenotype. Current efforts are underway to profile and RNA-Seq, with the other PIs of the award, the complete topological map of the field of injury in NSCLC patients and cancer-free individuals which are expected to yield airway biomarkers for lung cancer to be tested in future aims of the study.
- Anatomy and Physiology
- Medicine and Medical Research