Accession Number:

ADA574132

Title:

Shock Wave-Stimulated Periosteum for Cartilage Repair

Descriptive Note:

Annual rept. 30 Sep 2011 - 29 Mar 2012

Corporate Author:

BOSTON VA RESEARCH INST MA

Personal Author(s):

Report Date:

2012-04-01

Pagination or Media Count:

7.0

Abstract:

The primary objective of this project is to determine if extracorporeal shock wave ESW-stimulated periosteum improves cartilage repair when it is used as an autograft to fill a defect in the articular surface of goats. A miniature fiber optic pressure sensor will be inserted into the tibial periosteum of 6 animals to measure the actual shock waveform in the tissue for two ESW doses energy densities. In 12 goats, tibial periosteum stimulated by one of the 2 doses of ESWs n6 will be harvested, 4 days post-treatment, as an autograft for implantation into one 1 cm2 defect surgically produced in the trochlear groove of the knee joint of the same goat. Non-ESW-treated periosteum will serve as the control group n6. All animals will be sacrificed after 16 weeks, and the reparative tissue will be quantified histomorphometrically by determining the areal percentage of selected tissues in the original cartilage defect area.

Subject Categories:

  • Biology
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE