Evaluate the Mechanism of Enhanced Metastasis Induced by Arthritis
Annual summary 1 Sep 2009-31 Aug 2012
NORTH CAROLINA UNIV AT CHARLOTTE
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Breast cancer remains the second leading cause of cancer related deaths for women in the United States. Metastasis is regulated not only by intrinsic genetic changes in malignant cells, but also by the microenvironment, especially those associated with chronic inflammation. We have reported that mice that suffer from autoimmune arthritis have significantly increased incidence of bone and lung metastasis and decreased survival associated with breast cancer. In this study, we evaluated the mechanism underlying the increased metastasis.
- Anatomy and Physiology
- Medicine and Medical Research