Exploitation of P-glycoprotein Over-expression for Targeted Drug Delivery to Breast Cancer
Final rept. 15 Sep. 2010-14 Sep. 2011
CORNELL UNIV ITHACA NY
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This research resulted in the design and synthesis of new nanoconjugates with the ability to target multidrug resistant tumors. Additionally, the work has helped to initiate a new research program focused on the delivery of drugs to the brain. Both tracks of research are continuing in the PI s laboratory. Most surprisingly, we discovered that a simple P-gp substrate that has no other pharmacological effects, is easily conjugated to the delivery system and effectively targets MDR cells. This is particularly exciting because for drug targeting to the brain, having minimal off-target pharmacological activity is important toward the development of an effective delivery vehicle i.e., low side effects.
- Medicine and Medical Research