Accession Number:

ADA571769

Title:

Exploitation of P-glycoprotein Over-expression for Targeted Drug Delivery to Breast Cancer

Descriptive Note:

Final rept. 15 Sep. 2010-14 Sep. 2011

Corporate Author:

CORNELL UNIV ITHACA NY

Personal Author(s):

Report Date:

2011-10-01

Pagination or Media Count:

10.0

Abstract:

This research resulted in the design and synthesis of new nanoconjugates with the ability to target multidrug resistant tumors. Additionally, the work has helped to initiate a new research program focused on the delivery of drugs to the brain. Both tracks of research are continuing in the PI s laboratory. Most surprisingly, we discovered that a simple P-gp substrate that has no other pharmacological effects, is easily conjugated to the delivery system and effectively targets MDR cells. This is particularly exciting because for drug targeting to the brain, having minimal off-target pharmacological activity is important toward the development of an effective delivery vehicle i.e., low side effects.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE