Role of Natural Killer T Cells In Immunogenic Chemotherapy for Breast Cancer
Annual summary 1 Sep 2011-31 Aug 2012
MELBOURNE UNIV PARKVILLE (AUSTRALIA)
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During this first year of investigation, we have highlighted the important role of gamma delta T cells in the efficacy of immunogenic chemotherapy using anthracyclines. In the meantime, the NKT cells seem to be dispensable for this effect at least in this particular situation. Moreover, we have also identified a population of gamma delta T cells with a unique phenotype never described before CD3expn bright. Interestingly, this population has a clear intrinsic ability to produce IL-17 compared to any other gamma delta T cells and are represented at a high frequency in breast cancer tumor environment. Our future efforts will focus on this population and their putative role in immunogenic chemotherapy for breast cancer.
- Anatomy and Physiology
- Medicine and Medical Research