Therapeutic Correction of Thrombin Generation in Dilution-Induced Coagulopathy: Computational Analysis Based on a Data Set of Healthy Subjects
ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD TELEMEDICINE AND ADVANCED TECH RESEARCH CENTER
Pagination or Media Count:
Prothrombin complex concentrates PCCs, which contain different coagulation proteins, are attractive alternatives to the standard methods to treat dilution-induced and, generally, traumatic coagulopathy. We investigated the ability of a novel PCC composition to restore normal thrombin generation in diluted blood. The performance of the proposed PCC composition coagulation factors F II, IX, and X and the anticoagulant antithrombin, designated PCC-AT, was compared with that of FVIIa and PCC-FVII, which is the PCC composition containing FII, FVII, FIX, and FX main components of most PCCs.
- Medicine and Medical Research