Accession Number:

ADA571133

Title:

Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD INTEGRATED TOXICOLOGY DIVISION

Report Date:

2012-04-02

Pagination or Media Count:

6.0

Abstract:

An in silico screen of the NIH Molecular Library Small Molecule Repository MLSMR of 350000 compounds and confirmatory bioassays led to identification of chaetochromin A 1 as an inhibitor of botulinum neurotoxin serotype A BoNT A. Subsequent acquisition and testing of analogues of 1 uncovered two compounds, talaroderxines A 2 and B 3, with improved activity. These are the first fungal metabolites reported to exhibit BoNTA inhibitory activity.

Subject Categories:

  • Biochemistry
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE