Accession Number:

ADA571105

Title:

Glycomic Analysis of Prostate Cancer

Descriptive Note:

Final rept. 1 Jul 2009-30 Jun 2012

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2012-07-01

Pagination or Media Count:

17.0

Abstract:

We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions analysis of the IgAIgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE