Glycomic Analysis of Prostate Cancer
Final rept. 1 Jul 2009-30 Jun 2012
GEORGETOWN UNIV WASHINGTON DC
Pagination or Media Count:
We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions analysis of the IgAIgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.
- Medicine and Medical Research