Accession Number:

ADA571033

Title:

Nanoscale Probing of Electrical Signals in Biological Systems

Descriptive Note:

Final rept. 5 Apr 2005-4 Nov 2011

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL

Personal Author(s):

Report Date:

2012-03-18

Pagination or Media Count:

37.0

Abstract:

An improved molecular-level description of trans-membrane ion currents has the potential to impact many areas of military and civilian importance such as disease diagnosis, drug developmentscreening, and technologies that interface between living cells and microelectronic circuitry. Ultimately, these developments would imply improvements in health and quality of life for individuals that have suffered from injuries or wounds that have compromised senses such as sight and hearing. Furthermore, technologies involving the human-machine interface and disease diagnosistreatment are likely to be positively impacted. This AROYIPPECASE, entitled Nanoscale Probing of Electrical Signals in Biological Systems, is developing conductive atomic force microscopy AFM techniques, such as scanning electrochemical microscopy SECM and scanning ion conductance microscopy SICM, with the potential to improve the spatial resolution of trans-membrane ion channel measurements by at least an order of magnitude over the current state-of-the art. In addition, nanostructured biocompatible neural stimulation electrodes are being fabricated and characterized. Beyond trans-membrane ion channels, advanced SECM and SICM methods have also been applied to other materials systems including electrochemically active electrodes, nanocomposites, graphene, and photovoltaics.

Subject Categories:

  • Medicine and Medical Research
  • Electrical and Electronic Equipment

Distribution Statement:

APPROVED FOR PUBLIC RELEASE