tRNA and Its Activation Targets as Biomarkers and Regulators of Breast Cancer
Annual rept. 1 Sep 2011-31 Aug 2012
CHICAGO UNIV IL
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Breast cancer refers to a variety of types that each derive from distinct causes and merit different treatments. It is crucial to develop new classes of molecules that target heretofore unexplored cellular mechanisms, so that tumors not responsive to current treatments might be responsive to new routes of therapy. We are exploring a previously under-appreciated avenue that can lead to precise identification of breast cancer sub-types to improve treatment options and identify new therapeutic targets. The genetic code is decoded by transfer RNA tRNA. We discovered that breast tumors have high levels of tRNA and tRNA over-expression has an aberrant pattern suggesting that tumors use tRNA over-expression to mis-regulate the synthesis of some crucial proteins. Further, we found that a specific tRNA is an oncogene in breast cells suggesting that tRNA over- expression could even originate the development of breast cancer. We are identifying the mis-regulation targets of tRNA over- expression in breast cancer to serve as biomarkers and establishing the potential of targeting tRNA as a new route for breast cancer treatment.
- Medicine and Medical Research