Evaluating the Potential of Adipose Tissue-Derived MSCs as Anticancer Gene Delivery Vehicles to Bone-Metastasized Prostate Cancer
Final rept. 1 Apr 2009-30 Sep 2010
TULANE UNIV MEDICAL CENTER NEW ORLEANS LA
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Several publications have shown clear evidence of tumor-site specific localization of Adipose stem cells ASC. Therefore, tumor-homing potential of ASCs are promising tools for delivering anti-cancer genes to metastatic sites. However, studies have documented that only a small percentage of the systemically injected ASCs are actually recruited to the tumor site. Furthermore, when cotransplanted with tumor cells in vivo, studies also showed that certain ASCs may increase tumor growth. Thus, identification of the tumorpromoting phenotype in ASCs, and a selection strategy to enrich ASCs with non-tumor-promoting activity but enhanced tumor-homing potential, will be crucial.
- Anatomy and Physiology
- Medicine and Medical Research