Accession Number:

ADA568974

Title:

Sealing Penetrating Eye Injuries with Photoactivated Bonding

Descriptive Note:

Final rept. 1 Sep 2009-31 Aug 2012

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

2012-09-01

Pagination or Media Count:

24.0

Abstract:

The purpose of this report is to develop a light-activated technology called PTB with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. Scope To compare light-activated bonding of amnion to direct sealing of penetrating cornea wounds, to evaluate photobonding for puncture wounds in sclera, and to evaluate safety of photobonding to the iris. Major findings Identified the treatment parameters for rapidly and strongly sealing amniotic membrane over scleral puncture wounds. Demonstrated that photobonding amion effectively sealed wounds spanning the cornea sclera. Determined that sealing penetrating cornea wounds using a dye-stained amniotic membrane patch and green light is superior to direct photo-activated bonding of the wound walls. Established that the green light parameters used to seal amnion over cornea wounds are below the threshold for thermal damage to the iris.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE