Fasciotomy Reduces Compartment Pressures and Improves Recovery in a Porcine Model of Extremity Vascular Injury and Ischemia/Reperfusion
Final rept. Sep 2010-Oct 2012
AIR FORCE MEDICAL WING (59TH) WILFORD HALL AMBULATORY SURGICAL CENTER LACKLAND AFB TX CLINICAL RESEARCH DIV
Pagination or Media Count:
The objective of this study is to establish a model of extremity compartment syndrome following vascular injuryhemorrhage and ischemiareprovision. An additional objective is to determine the effect of fasciotomy on measures of neuromuscular recovery. Methods Yorkshire swinee 75-5kg underwent 35 blood volume hemorrhage, followed by 1, 3 and 6 hours of ischemia n-17 1HR, 3HR, 6HR via iliac artery occlusion followed by repair and reperfusion. A second cohort n18 underwent fasciotomy of the anterior compartment of the hind limb following vascular repair lHRwF 3HRwF, 6HR-F. Compartment pressures and measures of electromyographic EMG recovery were performed throughout a 14 day survival period and tissue histology examined at the completion of the study.
- Medicine and Medical Research