Accession Number:

ADA568740

Title:

Maintenance of Epithelial Stem Cells by Cbl Proteins

Descriptive Note:

Annual rept. 1 Sep 2011-31 Aug 2011

Corporate Author:

NEBRASKA UNIV MEDICAL CENTER OMAHA

Personal Author(s):

Report Date:

2012-09-01

Pagination or Media Count:

78.0

Abstract:

The Cbl family E3 ubiquitin ligases are critical regulators of tyrosine kinase-mediated signal transduction, and we and others demonstrated that the Cbl family proteins were required to maintain the homeostasis of the hematopoietic stem cell compartment and disturbance of this critical regulatory pathway led to cancer in human and mice. However, their roles in the epithelial stemprogenitor cells has never been examined. Using the newly-established hTERT-immortalized human mammary epithelial cell hMEC line hereafter called TERT-hMEC, we demonstrated that loss of Cbl inhibited differentiation of epithelial cells. Our preliminary studies indicate that Cbl functions in multiple signaling pathways beyond the traditional EGFR pathway, which appears to be responsible for the complex phenotypes of Cbl deficiency in the epithelial compartment.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE