New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury
Annual rept. 10 Jan 2011-9 Jan 2012
HARVARD COLL CAMBRIDGE MA
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We have been developing robust low-magnetic-field implementations of MRI LFI focused on brain imaging. In particular we have expanded our development of the LFI test bed to include two complimentary approaches electromagnet and permanent magnet based test bed scanner systems. We are also developing injury-sensitive MRI based on converting the electron spin of free radicals associated with injury into nuclear polarization using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI OMRI. Much of the hardware development of the human head LFI test bed systems and the OMRI system is now complete. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact and could be transformative, enabling improved diagnosis and monitoring of battlefield injuries prevalent in TBI.
- Medicine and Medical Research