Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks
MILITARY ACADEMY WEST POINT NY
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We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various shells based on network structure. We observe that shells with a higher average degree are more highly targeted with a power-law relationship and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.
- Genetic Engineering and Molecular Biology