Accession Number:

ADA568374

Title:

Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks

Descriptive Note:

Journal article

Corporate Author:

MILITARY ACADEMY WEST POINT NY

Personal Author(s):

Report Date:

2012-09-21

Pagination or Media Count:

8.0

Abstract:

We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various shells based on network structure. We observe that shells with a higher average degree are more highly targeted with a power-law relationship and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE