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Detection of Early Lung Cancer Among Military Personnel (DECAMP)

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Annual rept. 30 Sep 2011-29 Sep 2012

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The purpose of this work is to develop and validate molecular biomarkers found in blood, other bodily fluids, or tissues, which may be used for the early detection of lung cancer in Military Treatment Facilities and Veteran s Administration Hospitals. Over the course of the first year of this award, we have developed the infrastructure needed for launching two distinct clinical trials via establishment of detailed protocols, CRFs and SOPs for both studies. Project 1 will recruit 500 patients with indeterminate pulmonary nodules, identifying 75 with lung cancer and 75 matched controls, to validate existing diagnostic biomarkers in the blood and airway. The ACRIN- and HRPO-approved protocol for Project 1 has been submitted to local IRBs at each site, with several sites having received approval and set to begin recruitment post-training. Protocol 2 will recruit a cross-sectional cohort of smokers with early stage lung cancer n50 and matched controls n30 along with a longitudinal cohort of 850 high-risk smokers in order to develop molecular biomarkers for the preclinical detection of lung cancer. This protocol has been approved by HRPO and ACRIN and has been submitted to local IRBs. We have further developed the administrative infrastructure to support clinical and imaging data collection at each site along with biosample collection and shipping between the clinical and research sites. This work has set the stage for developing less-invasive measures for the early detection of lung cancer, ultimately decreasing the number of deaths attributable to the disease.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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