Association of Cytokine Candidate Genes with Severity of Pain and Co-Occurring Symptoms in Breast Cancer Patients Receiving Chemotherapy
Annual summary rept. 15 Sep 2011-14 Oct 2012
CALIFORNIA UNIV SAN FRANCISCO
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The purpose of the proposed project is to identify common genetic variations i.e., single nucleotide polymorphisms and haplotypes in cytokine genes, as well as psychological characteristics that are significantly associated with the severity of pain and co-occurring symptoms i.e., fatigue, sleep disturbance, and depressive symptoms in a sample of women receiving chemotherapy for breast cancer. Using cluster analysis, our team has previously and consistently found two extreme patient subgroups patients who report symptoms uniformly low i.e., low scores on pain, fatigue, sleep disturbance, and depressive symptom inventories, and patients who report symptoms as more severe i.e., high scores on all four symptom inventories. By the end of Year 1, 236 breast cancer patients were enrolled across the three research sites UCSF, Alta Bates Summit Medical Center, and El Camino Hospital, and data collection forms were scanned and output to statistical analysis software. Moreover, the DNA samples of the participants were sent to the UCSF Genome Core for genotyping, and we expect that genotyping will be complete within the next two months.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research