Mobilization of Neural Precursors in the Circulating Blood of Patients with Multiple Sclerosis
Revised annual rept. 1 Jul 2011-30 Jun 2012
CHICAGO UNIV IL
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Relapsing remitting multiple sclerosis RRMS is demyelinating disease that affects both men and women and is characterized by cycles of acute myelin loss, followed by remission with active myelin repair. The mechanism and the cellular source for remyelination are still in discussion, but there is evidence for the involvement of adult oligodendrocyte progenitor cellsOPCs. In this study, we hypothesized that circulating precursor cells identified by the presence of the cell surface marker CD133 may be of relevance during MS and for CNS repair processes. We measured the abundance of CD133 and CD34 cells in peripheral blood collected from RRMS patients and healthy controls. Our results showed that circulating CD34 cells were not significantly affected by the disease. In contrast, CD133 cells were significantly reduced in the RRMS patients recruited in this study. Interestingly, when CD133 values from RRMS women were compared to RRMS men, we found that women had significantly lower values than the men p0.029. The fraction of hematopoietic CD133 cells that were positive for the CD34 marker was significantly elevated in RRMS patients. Our findings point to gender differences in the number of circulating progenitor cells in MS patients, and suggest that a reductions in CD133 cells in RRMS may be exploited as a tool to diagnose RRMS.
- Anatomy and Physiology
- Medicine and Medical Research